Natural Product as biopesticides

Driven by the challenge for a better planet , Hedera-22 is dedicated to creating sustainable plant protection products. The agricultural market faces significant challenges, that demand innovative solutions. Natural Products, as sustainable biopesticides, are part of the answer.

Leveraging our core competencies and accelerated process, Hedera-22 seeks to partner with agricultural leaders to develop solutions for the future. With our extensive library of patentable molecules, we are paving the way for groundbreaking advancements to a sutainable bioeconomy.

A unique technology platform

to drastically increase the output, diversity and maturity of unique cryptic metabolites !

In-vitro lab Synthesis

Hedera-22 has pioneered an innovative method that overcomes the traditional challenges of strain collection maintenance, culture and extraction operations. By harnessing the treasure trove of a vast library of genomes and environmental DNA, we unlock the full potential of natural product discovery.

CUTTING-EDGE Bioinformatics predictive approach

Hedera-22 employs a groundbreaking strategy, leveraging proprietary machine learning algorithms to accelerate biomolecule discovery. Our innovative approach integrates genome mining, metabolomics and structure prediction algorithms, facilitating the rapid identification of next-generation compounds. This selective and focused methodology streamlines the discovery process, unlocking new possibilities in biomolecule exploration.


In house preliminary assays assess antifungal and herbicidal bioactivity, as well as ecotoxicity.

Why Natural Products ?

Usually more bioavailable, Natural Products are more likely to resemble biosynthetic intermediates or endogenous metabolites, and hence take advantage of active transport mechanisms .

Nature has learned to maintain low hydrophobicity and intermolecular H-bond donating potential when it needs to make biologically active compounds with high molecular weight and large numbers of rotatable bonds.

Natural products and their derivatives have been recognized for many years as a source of therapeutic agents and structural diversity .

By mimicking certain distribution properties of natural products, combinatorial compounds can be substantially more diverse and have greater biological relevance than purely synthetic compounds.

Our main activities & services


For the identification of a new metabolite of natural origin with activity in agriculture as herbicide, fungicide, insecticide or stimulant.

Next generation BIOMOLECULEs library

Pre-characterized biomolecule catalog available for screening in the scope of licensing agreement.

Our Team

Hedera 22 has a strong interdisciplinary team with high level of expertise.


Valerie Renard


Lucas Rezende

Scientific coordinator



Micro & Molecular Biology


Metabolomics and biomolecular chemistry


Metabolomics and biomolecular chemistry


Lab Technician


Lab Technician


Lab Technician








Denis Baurain

Marc Hanikenne

Sebastien Rigali

Pierre Tocquin

about US

Science and technology for a better life.

 Hedera-22 was created in 2015 as a spin-off from University of Liège, to provide bio-informatics services. 

In 2020, Hedera-22 extended its activity to natural products discovery  using internal bio-informatic predictive tools.

After having validated its capabilities with several proof of concepts, Hedera-22 is today developing its unique technology platform that will allow to drastically increase the output, diversity and maturity of unique metabolites and build an extensive patentable molecule library.

Latest news

March 2024 : We are thrilled to share a significant milestone achieved by our scientific team in the realm of natural product discovery ! 

Over the past months, Hedera-22 has been dedicated to revolutionizing the agricultural market by delving into in-vitro production of secondary metabolites, particularly focusing on potentially anti-fungal agents. Today,

we are proud to share that our efforts have borne fruit with a first successful lab scale production of bioactive natural molecules utilizing DNA-based synthesis

December 2023 : we are recruiting ! Are you a Research Scientist in Molecular Biology – Synthetic Biology with experience in cell free expression or recombinant protein expression. 

May 2023 : Hedera-22 is looking for new investors to support the development of its synthetic biology process that will leverage the discovery capabilities.

Contact us on

Jan 2023 : From bacteria to new antibiotic discovery ! Fantastic work in collaboration with  Séba Rigali, InBioS @ Uliège which represents a Proof of Concept of Hedera-22’s process.
Lunaemycins, first new bioactive molecules found from cave moonmilk-dwelling bacteria. See our work at  Lunaemycins, New Cyclic Hexapeptide Antibiotics from the Cave Moonmilk-Dweller Streptomyces lunaelactis MM109T – PubMed (

We are regularly expanding our team. Contact us for more info about open positions. (@ )

May 2022 : Discover our research article written in collaboration with the University of Liège – InBioS Center for Protein Engineering, GIGA Proteomics Facility and Mass Spectrometry Laboratory MolSys Research Unit – describing the discovery of 43  novel ferroverdin-like compounds from Streptomyces lunaelactis  species. Our collaborative work uncovered putative novel CETP inhibitors structurally related to ferroverdins.

Contact us

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