A unique technology platform

From host organisms to the production of new biomolecules… A complete in-house discovery pipeline  !

Proprietary Actinomycete collection

Hedera-22 has built its own actinomycetes library composed of strains collected in unfriendly environment giving them unique properties as they are more focussed and specific to the goal. Full genomics analysis of these strains constitute an unequaled matrix library.

Bioinformatic predictive approaches

Based on a AI driven methodology, the original strategy developed by Hedera-22 accelerates the next generation biomolecule discovery (up to 180 times faster than traditional methods).

in silico identification of the right bacteria able to biosynthesize cryptic compounds, their structure and bioactivity.

cutTing edge Metabolomics

State of the art molecular metabolomics equipment and methods for new biomolecule structure elucidation.

Molecular Microbiology

Improving production of new molecules with targeted genetic modifications. Bioactivity and ecotoxicity preliminary checks conducted in house.

The context

The challenge for better health and a better planet drives Hedera-22 towards the development of sustainable products for pharma and plant protection .

Building on our core competencies and accelerated process, we intend to partner with pharma and agro leaders to join them in the development of solutions for the future.

Natural Products

Usually more bioavailable, Natural Products are more likely to resemble biosynthetic intermediates or endogenous metabolites, and hence take advantage of active transport mechanisms .

Nature has learned to maintain low hydrophobicity and intermolecular H-bond donating potential when it needs to make biologically active compounds with high molecular weight and large numbers of rotatable bonds.

Natural products and their derivatives have been recognized for many years as a source of therapeutic agents and structural diversity .

By mimicking certain distribution properties of natural products, combinatorial compounds can be substantially more diverse and have greater biological relevance than purely synthetic compounds.

Our main activities & services

Next generation BIOMOLECULEs library

Pre-characterized biomolecule catalog available for screening for biological activity of interest.


Identification of optimal expression conditions for maximising the fermentation yield.


Identification of next generation biomolecules with pharma, agro or other activity in the scope of licensing or partnership agreement.


Screening and sequencing of microorganism genomes; complex biological data mining and genomic analysis.

Our Team

Hedera 22 team is competent, adaptable and dynamic. It is supported by the 4 founders who bring their expertise, fame and passion.


Valerie Renard


Sebastien Rigali



Aymeric Naome


Alice Raymackers

Micro & Molecular Biology

Benoit Deflandre

Micro & Molecular Biology

Loïc Martinet


Lucas Rezende


Alice Jadoul

Lab Technician


Denis Baurain


Marc Hanikenne


Sebastien Rigali

Founder & CSO

Pierre Tocquin


about US

Science and technology for a better life.

Hedera-22 was created in 2015 as a spin-off from ULiege.

 Its first activity was based on the development of bioinformatics competencies and the informatic treatment of massive biological data combined with « omic » biology expertise (genomics, proteomics, metabolomics). 

In 2020, Hedera-22 raised funds to pursue its activity in a wider field. It positions itself as a partner to industries active in research and development of innovative products based on the use of new natural molecules of agronomic, pharmaceutical or other interest.

Latest news

We are looking forward to welcome 2 skilled team members:

Benoit Deflandre as from December 1st on – Benoit is finalizing its PhD in Molecular Bacteriology (CIP/ULiège) –

and Lucas Rezende in very early 2022 – Lucas has a PostDoc in chemistry from KUL and Sao Paulo Universities and was vice Professor in UFES University (Brasil).

contact information


    Chemin de la Vallée 4

    4000 Liege – Belgium

    google.be :  50°34’41.3″N 5°34’32.9″E